Tenofovir disoproxil fumarate is an antiretroviral drug. In the present work, a simple, sensitive, specific method has been developed for the quantitative estimation of tenofovir disoproxil fumarate in bulk and pharmaceutical dosage form. Tenofovir disoproxil fumarate reacts with NQS reagent produce a colour complex which shows absorption maxima at 453 nm. The linearity was found in concentration range of 20-100 μg/ml. The correlation coefficient was found to be 0.9915. The method was validated as per ICH guidelines.
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